Pharmacophore-based small molecule CXCR4 ligands

Pharmacophore-based small molecule CXCR4 ligands Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: The insertion of an (E)-alkene dipeptide isostere into the βII′-turn moiety Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140 Identification of the hydantoin alkaloids parazoanthines as novel CXCR4 antagonists by computational and in vitro functional characterization Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection CD4 mimics targeting the HIV entry mechanism and their hybrid molecules with a CXCR4 antagonist Synthesis and structure–activity relationship of benzetimide derivatives as human CXCR3 antagonists Structure−Activity Relationships in the Binding of Chemically Derivatized CD4 to gp120 from Human Immunodeficiency Virus New bicyclam–GalCer analogue conjugates: synthesis and in vitro anti-HIV activity