A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes

A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes C1 and N5 derivatives of cerpegin: Synthesis of a new series based on structure–activity relationships to optimize their inhibitory effect on 20S proteasome New C4- and C1-derivatives of furo[3,4-c]pyridine-3-ones and related compounds: Evidence for site-specific inhibition of the constitutive proteasome and its immunoisoform New betulinic acid derivatives as potent proteasome inhibitors Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome Vinyl ester-based cyclic peptide proteasome inhibitors α,β-Unsaturated N-Acylpyrrole Peptidyl Derivatives: New Proteasome Inhibitors Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome