Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents Nucleotidic prodrugs of anti-HIV dideoxynucleosides Lipophilic, Acid-Stable, Adenosine Deaminase-Activated Anti-HIV Prodrugs for Central Nervous System Delivery. 2. 6-Halo- and 6-Alkoxy Prodrugs of 2'-.beta.-Fluoro-2',3'-dideoxyinosine Potential prodrug derivatives of 2',3'-didehydro-2',3'-dideoxynucleosides. Preparations and antiviral activities Simple mono-derivatisation of the aryl moiety of D4A and DDA-based phosphoramidate prodrugs significantly enhances their anti-HIV potency in cell culture Highly water-soluble lipophilic prodrugs of the anti-HIV nucleoside analog 2',3'-dideoxycytidine and its 3'-fluoro derivative Mononucleoside phosphorodithiolates as mononucleotide prodrugs PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer Phosphoramidate derivatives of 2′,3′-didehydro-2′,3′-dideoxyadenosine [d4A] have markedly improved anti-HIV potency and selectivity Potential anti-AIDS drugs. Lipophilic, adenosine deaminase-activated prodrugs