‘Click’ synthesis of a triazole-based inhibitor of Met functions in cancer cells

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

The use of Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition permitted the synthesis of a new compound that is able to inhibit the HGF-induced scattering of MDCK (epithelial cells) and in vitro tumorigenesis of H1437 (non-small-cell lung cancer) and GTL-16 (human gastric carcinoma). In agreement with biochemical and biological results, docking studies within the ATP binding site of Met suggested for the new synthesized compound a binding mode similar to that of the active compound Triflorcas previously reported.

Knowledge Graph

Similar Paper

‘Click’ synthesis of a triazole-based inhibitor of Met functions in cancer cells
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition
European Journal of Medicinal Chemistry 2010.0
Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties
European Journal of Medicinal Chemistry 2019.0
Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Design and synthesis of 1,2,3-triazolo-phenanthrene hybrids as cytotoxic agents
Bioorganic & Medicinal Chemistry Letters 2017.0
Synthesis and antiproliferative evaluation of 3,5-disubstituted 1,2,4-triazoles containing flurophenyl and trifluoromethanephenyl moieties
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells
Bioorganic & Medicinal Chemistry Letters 2013.0
New amide linked dimeric 1,2,3-triazoles bearing aryloxy scaffolds as a potent antiproliferative agents and EGFR tyrosine kinase phosphorylation inhibitors
Bioorganic & Medicinal Chemistry Letters 2019.0
N-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a New Scaffold that Provides Rapid Access to Antimicrotubule Agents: Synthesis and Evaluation of Antiproliferative Activity Against Select Cancer Cell Lines
Journal of Medicinal Chemistry 2010.0