The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product Synthesis and characterization of a small analogue of the anticancer natural product leinamycin Synthesis and Cytotoxicity of Leinamycin Antibiotic Analogues Synthesis and evaluation of 8,4′-dideshydroxy-leinamycin revealing new insights into the structure–activity relationship of the anticancer natural product leinamycin Possible chemical mechanisms underlying the antitumor activity of S-deoxyleinamycin Synthesis and Antitumor Activity of Novel Thioester Derivatives of Leinamycin Noncovalent DNA Binding Drives DNA Alkylation by Leinamycin: Evidence That the <i>Z</i>,<i>E</i>-5-(Thiazol-4-yl)-penta-2,4-dienone Moiety of the Natural Product Serves as an Atypical DNA Intercalator Leinamycin, a new antitumor antibiotic from Streptomyces; Producing organism, fermentation and isolation. Leinamycin, a new antitumor antibiotic from Streptomyces; Producing organism, fermentation and isolation. Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells