Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

A series of fused and functionalized pyridine derivatives were designed, synthesized and tested for their potential antitubercular properties. All these novel compounds were prepared by using multistep methods involving the construction of pyridine ring as a key synthetic step. Some of these compounds were found to be interesting when tested for their antitubercular properties in vitro and one of them appeared as an attractive and potential antitubercular agent.

Knowledge Graph

Similar Paper

Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents
ACS Medicinal Chemistry Letters 2015.0
Design, synthesis and in vitro evaluation of antitubercular and antimicrobial activity of some novel pyranopyrimidines
European Journal of Medicinal Chemistry 2010.0
Design and synthesis of novel piperazine unit condensed 2,6-diarylpiperidin-4-one derivatives as antituberculosis and antimicrobial agents
Medicinal Chemistry Research 2012.0
Antimycobacterial activity of nitrogen heterocycles derivatives: Bipyridine derivatives. Part III [13,14]
European Journal of Medicinal Chemistry 2014.0
One pot synthesis of some novel coumarins containing 5-(substituted-2-hydroxybenzoyl) pyridine as a new class of antimicrobial and antituberculosis agents
Medicinal Chemistry Research 2013.0
Synthesis and biological evaluation of 1H-pyrrolo[2,3-d]pyrimidine-1,2,3-triazole derivatives as novel anti-tubercular agents
Bioorganic & Medicinal Chemistry Letters 2019.0
Design, synthesis, and biological evaluation of 4-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives as potent antitubercular agents
Bioorganic & Medicinal Chemistry Letters 2010.0
New 1,3-oxazolo[4,5-c]quinoline derivatives: Synthesis and evaluation of antibacterial and antituberculosis properties
European Journal of Medicinal Chemistry 2010.0
Synthesis and antituberculosis activity of indole–pyridine derived hydrazides, hydrazide–hydrazones, and thiosemicarbazones
Bioorganic & Medicinal Chemistry Letters 2016.0