Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

A series of 2,4,6-trisubstituted [1,3,5]triazines were synthesized and evaluated for their antimicrobial activity against two representative Gram-positive, Gram-negative bacteria and two fungi. Biological data revealed that among all the compounds screened, compounds 3f, 3g, 3h, 3i, 3m, 3o and 3p found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi. Out of the synthesized compounds seven analogues have shown MIC in the range of 6.25-12.5 μg/mL. These compounds were generally nontoxic and may prove useful as antimicrobial agents.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis and evaluation of 4-(substituted)-acetylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-triazole derivatives as antimicrobial agents
Medicinal Chemistry Research 2012.0
Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents
Bioorganic & Medicinal Chemistry Letters 2021.0
Synthesis, characterization, and antimicrobial evaluation of novel naphthalene-based 1,2,4-triazoles
Medicinal Chemistry Research 2012.0
Design, synthesis, characterization, and in vitro antimicrobial action of novel trisubstituted s-triazines
Medicinal Chemistry Research 2012.0
Synthesis and evaluation of 4-amino-5-phenyl-4H-[1,2,4]-triazole-3-thiol derivatives as antimicrobial agents
Medicinal Chemistry Research 2010.0
Synthesis and antibacterial activity of 2,4,6-tri substituted s-triazines
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives
Medicinal Chemistry Research 2013.0
Synthesis and antimicrobial evaluation of 4,5-diaryl-2-[4-(t-amino)-2-butynyl]-2,4-dihydro-3H-1,2,4-triazol-3-ones
Medicinal Chemistry Research 2012.0