New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms

Bioorganic & Medicinal Chemistry
2012.0

Abstract

New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole.

Knowledge Graph

Similar Paper

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms
Bioorganic & Medicinal Chemistry 2012.0
Synthesis and biological evaluation of quinoxaline di- N -oxide derivatives with in vitro trypanocidal activity
Bioorganic & Medicinal Chemistry Letters 2016.0
Synthesis and anti-Trypanosoma cruzi activity of derivatives from nor-lapachones and lapachones
Bioorganic & Medicinal Chemistry 2008.0
Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents
Bioorganic & Medicinal Chemistry Letters 2015.0
Trypanosoma cruzi: Activities of lapachol and α- and β-lapachone derivatives against epimastigote and trypomastigote forms
Bioorganic & Medicinal Chemistry 2008.0
On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions
European Journal of Medicinal Chemistry 2012.0
Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi
European Journal of Medicinal Chemistry 2008.0
1,2,5-Oxadiazole N-Oxide Derivatives and Related Compounds as Potential Antitrypanosomal Drugs:  Structure−Activity Relationships
Journal of Medicinal Chemistry 1999.0
2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities
Bioorganic & Medicinal Chemistry 2014.0
Growth inhibitory effect of naphthofuran and naphthofuranquinone derivatives on Trypanosoma cruzi epimastigotes
Bioorganic & Medicinal Chemistry Letters 1995.0