Literature

Abstract

The mouse Na+/taurocholate cotransporting polypeptide transiently expressed in COS-7 cells caused sodium-dependent uptake of [3H]taurocholic acid with Km and Vmax values of 18 microM and 102 pmol/mg protein/min, respectively. This Km value is comparable to that for rat NTCP and higher than that for human NTCP. Substrate specificity was evaluated by measuring inhibitory effects of unlabeled bile acids on [3H]taurocholic acid transport.

DOI： 10.1271/bbb.66.1116

Characterization of Cloned Mouse Na+/taurocholate Cotransporting Polypeptide by Transient Expression in COS-7 Cells

Bioscience, Biotechnology, and Biochemistry 2002.0

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.

Journal of Clinical Investigation 1994.0

Expression and characterization of a functional rat liver Na+ bile acid cotransport system in COS-7 cells

American Journal of Physiology-Gastrointestinal and Liver Physiology 1994.0

Substrate specificity of the rat liver Na+-bile salt cotransporter inXenopus laevisoocytes and in CHO cells

American Journal of Physiology-Gastrointestinal and Liver Physiology 1998.0

Characterization, cDNA Cloning, and Functional Expression of Mouse Heal Sodium-Dependent Bile Acid Transporter

Journal of Biochemistry 1999.0

Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake