Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

Daptomycin was shown to interact in vitro with pulmonary surfactant leading to reduction of its antibacterial activity. We report herein the preparation and anti-staphylococcal activity of a series of daptomycin analogs with reduced pulmonary surfactant interaction by replacing tryptophan with various amino acids.

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