Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents

Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents Design, synthesis and biological activity of N-substituted tetrahydropteroate analogs as non-classical antifolates against cobalamin-dependent methionine synthase and potential anticancer agents Novel 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives as dihydrofolate inhibitor: Design, synthesis and antifolate activity Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs Comparison of the biological effects of selected 5,8-dideazafolate analogs with their 2-desamino counterparts Folate analogs as inhibitors of thymidylate synthase Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogs of folic acid and aminopterin A potent multisubstrate analog inhibitor of human thymidylate synthetase