Synthesis and study of the antidepressant activity of novel 4,5-dihydro-7-alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives

Medicinal Chemistry Research
2012.0

Abstract

In this study, a novel series of 4,5-dihydro-7 alkoxy(phenoxy)-tetrazolo[1,5-a]quinoline derivatives was synthesized as potential antidepressant agents. Their antidepressant activities were evaluated by the forced swimming test and tail suspension test models. The pharmacological results showed that 7-(4-fluorobenzyloxy)-4,5-dihydrotetrazolo[1,5-a]quinoline 7j was found possessing strong activity in the both tests, especially in the FTS model, which was considered as the most promising compounds in this study.

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