Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6′-N-acetyltransferase and the role of 6′-NH2 in antibacterial activity 6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides Overexpression and Characterization of an Aminoglycoside 6'-N-Acetyltransferase with Broad Specificity from an  -Poly-L-lysine Producer, Streptomyces albulus IFO14147 AAC(6′)-Iaf, a Novel Aminoglycoside 6′- N -Acetyltransferase from Multidrug-Resistant Pseudomonas aeruginosa Clinical Isolates Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues Secondary aminoglycoside resistance in aminoglycoside-producing strains of Streptomyces The use of neamine as a molecular template: Inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3′-phosphotransferase type IIa