(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection

Journal of Medicinal Chemistry
2012.0

Abstract

A high-throughput, cell-based screen was used to identify chemotypes as inhibitors for human respiratory syncytial virus (hRSV). Optimization of a sulfonylpyrrolidine scaffold resulted in compound 5o that inhibited a virus-induced cytopathic effect in the entry stage of infection (EC₅₀ = 2.3 ± 0.8 μM) with marginal cytotoxicity (CC₅₀ = 30.9 ± 1.1 μM) and reduced viral titer by 100-fold. Compared to ribavirin, sulfonylpyrrolidine 5o demonstrated an improved in vitro potency and selectivity index.

Knowledge Graph

Similar Paper

(S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolidine-2-carboxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection
Journal of Medicinal Chemistry 2012.0
N-((1,3-Diphenyl-1H-pyrazol-4-yl)methyl)anilines: A novel class of anti-RSV agents
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors
Bioorganic & Medicinal Chemistry 2009.0
Synthesis and structure-activity relationship study of arylsulfonamides as novel potent H5N1 inhibitors
European Journal of Medicinal Chemistry 2018.0
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo
Bioorganic & Medicinal Chemistry Letters 2006.0
Design and synthesis of 2-((1H-indol-3-yl)thio)-N-phenyl-acetamides as novel dual inhibitors of respiratory syncytial virus and influenza virus A
European Journal of Medicinal Chemistry 2020.0
Synthesis and antiviral activity of a series of novel quinoline derivatives as anti-RSV or anti-IAV agents
European Journal of Medicinal Chemistry 2021.0
RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication
Antimicrobial Agents and Chemotherapy 2007.0
Design, synthesis, in vitro and in vivo anti-respiratory syncytial virus (RSV) activity of novel oxizine fused benzimidazole derivatives
European Journal of Medicinal Chemistry 2021.0
Potent Non-Nucleoside Inhibitors of the Measles Virus RNA-Dependent RNA Polymerase Complex
Journal of Medicinal Chemistry 2008.0