A series of substituted (benzamidostyryl) benzimidazole (3a–r) were synthesized and evaluated for their possible anti-inflammatory and ulcerogenicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority of the compounds were active in carrageenaninduced hind paw edema method test and compounds 3b, 3k had shown high potency after 3 and 4 h time intervals (P\0.001) almost equipotent to the standard drug indomethacin and showed less severity index than it.