Synthesis and antiviral activity of benzimidazolyl- and triazolyl-1,3,5-triazines

Medicinal Chemistry Research
2012.0

Abstract

A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs, two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 lg/ml, SI = 358; for compound 5r: EC50 = 5.0 lg/ml, SI = 300) in comparison to acyclovir.

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