An efficient one-pot cyclization of quinoline thiosemicarbazones to quinolines derivatized with 1,3,4-thiadiazole as anticancer and anti-tubercular agents

Medicinal Chemistry Research
2012.0

Abstract

A series of 6,7,8-substituted thiosemicarbazones (2a–j) of 2-chloro-3-formyl-quinoline derivatives were cyclized to the title compounds (3a–j) using acetic anhydride. The structures of the final compounds (3a–j) were confirmed by elemental and spectral (IR, 1 H NMR and MS) analysis. Some of the title compounds have shown promising anticancer and antitubercular activities.

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