Synthesis and antimicrobial activities of novel bisacridine-1,8-dione derivatives

Medicinal Chemistry Research
2011.0

Abstract

A series of bisacridine-1,8-dione derivatives were synthesized by one-pot reaction of aromatic dialdehydes, dimedone or cyclohexane-1,3-dione and primer aromatic amines in acetonitrile to utilizing Amberlyst-15 as a heterogeneous catalyst. The structures of compounds were characterized by FT-IR, NMR, and elemental analysis. Antimicrobial activities of these compounds were determined by using the disc diffusion method against to these gram-positive and gram-negative bacteria and yeast. The results were compared with reference discs.

Knowledge Graph

Similar Paper

Synthesis and antimicrobial activities of novel bisacridine-1,8-dione derivatives
Medicinal Chemistry Research 2011.0
Synthesis and antimicrobial activity of some bisoctahydroxanthene-1,8-dione derivatives
Medicinal Chemistry Research 2011.0
Synthesis, characterization and antimicrobial activities of some novel bis-chalcones
Medicinal Chemistry Research 2012.0
Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives
European Journal of Medicinal Chemistry 2009.0
Synthesis of new 2-substituted pyrido[2,3-d]pyrimidin-4(1H)-ones and their antibacterial activity☆
European Journal of Medicinal Chemistry 2009.0
Synthesis, antimicrobial activity and structure–activity relationship study of N,N-dibenzyl-cyclohexane-1,2-diamine derivatives
European Journal of Medicinal Chemistry 2011.0
Regioselective synthetic approaches towards 1,2,8,9-tetraazadispiro[4.1.4.2]trideca-2,9-dien-6-ones of potential antimicrobial properties
European Journal of Medicinal Chemistry 2009.0
Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents
European Journal of Medicinal Chemistry 2010.0
One-pot synthesis and antibacterial activities of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-dione derivatives
Bioorganic & Medicinal Chemistry Letters 2008.0
A facile, one-pot synthesis, characterization and antimicrobial activity of o-hydroxy anilide derivatives and 1-substituted-1,3-dicyclohexylurea analogs of long chain carboxylic acids
European Journal of Medicinal Chemistry 2011.0