1-Phenyl-3-toluyl-4-[ortho-1′-(N-ethyl-2′-methylpropylamine)]phenylpyrazole, synthesis and evaluation of the in vitro antifungal activity against Botrytis cinerea and Fusarium oxysporum

Il Farmaco
2004.0

Abstract

A novel antifungal pyrazole derivative was synthesized. Designated 1-phenyl-3-toluyl-4-[ortho-1'-(N-ethyl-2'-methylpropylamine)]phenylpyrazole, the compound exerted an antifungal effect toward Botrytis cinerea and Fusarium oxysporum. In fact, our results clearly show that mycelial growth and conidial germination of both fungi were blocked by the compound. Indeed, a 96-well microbioassay procedure was used for fast and easy evaluation of minimal inhibitory concentration (MIC). The MIC values for B. cinerea and F. oxysporum were 25 and 36 microg/ml, respectively.

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