Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones

Bioorganic & Medicinal Chemistry Letters
2013.0

Abstract

A novel series of 5(R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl]oxazolidinones having various piperidine group were synthesized and evaluated antibacterial activity against clinically isolated resistant strains of Gram-positive and Gram-negative bacteria. The compound 12a having exo-cyanoethylidene group in the 4-position of piperidine ring was found to be two to threefold more potent than the linezolid against penicillin-resistant Staphylococcus pneumonia and Staphylococcus agalactiae, and also exhibited reduced MAO-B inhibitory activity.

Knowledge Graph

Similar Paper

Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2013.0
Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones
European Journal of Medicinal Chemistry 2009.0
Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones
Bioorganic & Medicinal Chemistry Letters 2007.0
Piperazinyl Oxazolidinone Antibacterial Agents Containing a Pyridine, Diazene, or Triazene Heteroaromatic Ring
Journal of Medicinal Chemistry 1998.0
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2013.0
Novel 4-N-substituted aryl but-3-ene-1,2-dione derivatives of piperazinyloxazolidinones as antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2009.0
Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and in vitro antibacterial activities of novel oxazolidinones☆
European Journal of Medicinal Chemistry 2008.0
Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and antibacterial evaluation of novel oxazolidinone derivatives containing a piperidinyl moiety
Bioorganic & Medicinal Chemistry Letters 2019.0