Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives

Bioorganic & Medicinal Chemistry Letters
2013.0

Abstract

A series of novel indole-imidazole derivatives have been prepared and evaluated in vitro on the aromatase inhibitory activities. The results suggested that proton or a small electron-withdrawing group at para-position of the phenyl ring would enhance the inhibitory activities and any bulky group should be avoided in order to keep a relative small volume for this kind of molecules.

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