Triazolopyridazine LRRK2 kinase inhibitors

Triazolopyridazine LRRK2 kinase inhibitors Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2 Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond The development of CNS-active LRRK2 inhibitors using property-directed optimisation Design and Synthesis of Pyrrolo[2,3-d]pyrimidine-Derived Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Checkpoint Kinase 1 (CHK1)-Derived Crystallographic Surrogate A multicomponent pharmacophore fragment-decoration approach to identify selective LRRK2-targeting probes Leucine rich repeat kinase 2 (LRRK2) inhibitors based on indolinone scaffold: Potential pro-neurogenic agents New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck Development of (S)-N⁶-(2-(4-(Isoquinolin-1-yl)piperazin-1-yl)ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and Its Analogue as a D3 Receptor Preferring Agonist: Potent in Vivo Activity in Parkinson’s Disease Animal Models Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model