Conjugation of l-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production

Bioorganic & Medicinal Chemistry Letters
2013.0

Abstract

A series of 10 compounds resulting from the conjugation of O-prenylated naturally occurring benzoic and cinnamic acids to l-NAME were synthesized and tested together with the corresponding unprenylated parent molecule as anti-inflammatory agents for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophages. Results indicated that the coupling between O-geranyl and O-isopentenylcinnamic acids and l-NAME led to products with an enhanced activity when compared to the parent compounds.

Knowledge Graph

Similar Paper

Conjugation of l-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production
Bioorganic & Medicinal Chemistry Letters 2013.0
Dihydrostilbenes and diarylpropanes: Synthesis and in vitro pharmacological evaluation as potent nitric oxide production inhibition agents
Bioorganic & Medicinal Chemistry Letters 2016.0
Nitric oxide production inhibition and mechanism of phenanthrene analogs in lipopolysaccharide-stimulated RAW264.7 macrophages
Bioorganic & Medicinal Chemistry Letters 2016.0
Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE 2 in LPS-induced RAW 264.7 cells
Bioorganic & Medicinal Chemistry Letters 2017.0
Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and in vitro evaluation of homoisoflavonoids as potent inhibitors of nitric oxide production in RAW-264.7 cells
Bioorganic & Medicinal Chemistry Letters 2018.0
Oleanolic acid analogs as NO, TNF-α and IL-1β inhibitors: Synthesis, biological evaluation and docking studies
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and evaluation of new α-methylene-γ-lactone carbamates with NO production inhibitory effects in lipopolysaccharide-induced RAW 264.7 macrophages
European Journal of Medicinal Chemistry 2015.0
Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives
European Journal of Medicinal Chemistry 2011.0
Synthesis and structure–activity relationships of guaiane-type sesquiterpene lactone derivatives with respect to inhibiting NO production in lipopolysaccharide-induced RAW 264.7 macrophages
European Journal of Medicinal Chemistry 2014.0