Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity

Bioorganic & Medicinal Chemistry Letters
2013.0

Abstract

It is the first report of 1,3,4,5-tetrasubstituted 1,2,3,6-tetrahydropyrimidines derivatives, catalyzed by ZrOCl2. The mild reaction conditions, excellent yields in shorter reaction time and evasion of cumbersome workup procedures make this process economically lucrative for industrial application. The novelty and highlight of the present method is the promising antibacterial and antifungal activity shown by compounds (4a, 4b, 4e, 4f, 4h and 4l) compared to standard.

Knowledge Graph

Similar Paper

Green synthesis of tetrahydropyrimidine analogues and evaluation of their antimicrobial activity
Bioorganic & Medicinal Chemistry Letters 2013.0
An efficient synthesis, characterization, and antimicrobial screening of tetrahydropyrimidine derivatives
Medicinal Chemistry Research 2014.0
Microwave assisted nano (ZnO–TiO2) catalyzed synthesis of some new 4,5,6,7-tetrahydro-6-((5-substituted-1,3,4-oxadiazol-2-yl)methyl)thieno[2,3-c]pyridine as antimicrobial agents
Bioorganic & Medicinal Chemistry Letters 2013.0
Green synthesis and antimicrobial evaluation of some new trifluoromethyl-substituted hexahydropyrimidines by grinding
European Journal of Medicinal Chemistry 2011.0
A facile route for the synthesis 1,4-disubstituted tetrazolone derivatives and evaluation of their antimicrobial activity
Medicinal Chemistry Research 2013.0
A facile green synthesis and in vitro antimicrobial activity 4H-pyrimido[2,1-b][1,3]benzothiazole derivatives using aluminum trichloride under solvent free conditions
Medicinal Chemistry Research 2012.0
Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives
European Journal of Medicinal Chemistry 2010.0
Synthesis and in vitro microbiological evaluation of novel 4-aryl-5-isopropoxycarbonyl-6-methyl-3,4-dihydropyrimidinones
European Journal of Medicinal Chemistry 2010.0
A regioselective synthesis of some new pyrazol-1′-ylpyrazolo[1,5-a]pyrimidines in aqueous medium and their evaluation as antimicrobial agents
European Journal of Medicinal Chemistry 2011.0
Synthesis and biological evaluation of 5,7-diaryl-4,4-dimethyl-4,5,6,7-tetrahydropyridino[3,4-d]-1,2,3-thiadiazoles
Medicinal Chemistry Research 2007.0