DABCO-promoted one-pot synthesis of heteroaryl-substituted benzenes and their biological evaluation

Medicinal Chemistry Research
2014.0

Abstract

A simple and efficient one-pot synthesis of heteroaryl-substituted benzenes has been developed via cyclocondensation of vinylmalononitriles and ethylvinylcyanoacetates with heteroarylnitroolefines using diazabicyclo[2,2,2]octane as catalyst. The titled compounds were evaluated for their antitubercular, antibacterial and antifungal activities at various concentrations.

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