Synthesis of amino-hydroxy-benzocycloheptenones as potent, selective, non-peptidic dinuclear zinc metalloaminopeptidase inhibitors

Synthesis of amino-hydroxy-benzocycloheptenones as potent, selective, non-peptidic dinuclear zinc metalloaminopeptidase inhibitors Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors Amino-benzosuberone: A novel warhead for selective inhibition of human aminopeptidase-N/CD13 Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on α-Hydroxy-β-amino Acid Derivatives of Bestatin Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitors Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions Novel β-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN) First synthesis of α-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: Inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group A library of novel hydroxamic acids targeting the metallo-protease family: Design, parallel synthesis and screening Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I