Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis

Bioorganic & Medicinal Chemistry Letters
2013.0

Abstract

A variety of cholestan-3β-ol derivatives, which are oxygenated at different positions of the steroid ring system, were prepared and tested for their inhibition of the Mycobacterium tuberculosis H37Rv strain. Several compounds showed significant antitubercular activities with MIC90 values in the range 4-8 μM and low or non-detectable toxicity against mammalian cells.

Knowledge Graph

Similar Paper

Inhibitory effect of oxygenated cholestan-3β-ol derivatives on the growth of Mycobacterium tuberculosis
Bioorganic & Medicinal Chemistry Letters 2013.0
Inhibition of <i>Mycobacterium </i><i>t</i><i>uberculosis</i> Growth by Saringosterol from <i>Lessonia </i><i>n</i><i>igrescens</i>
Journal of Natural Products 2001.0
Anti-tuberculosis activity and structure–activity relationships of oxygenated tricyclic carbazole alkaloids and synthetic derivatives
Bioorganic &amp; Medicinal Chemistry 2017.0
Synthesis and antitubercular activity of 2-hydroxy-aminoalkyl derivatives of diaryloxy methano phenanthrenes
Bioorganic &amp; Medicinal Chemistry Letters 2005.0
[1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains
Bioorganic &amp; Medicinal Chemistry Letters 2007.0
Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular agents
Bioorganic &amp; Medicinal Chemistry Letters 2013.0
Synthesis of Leubethanol derivatives and evaluation against Mycobacterium tuberculosis
Bioorganic &amp; Medicinal Chemistry 2012.0
Synthesis and antitubercular activity of 7-chloro-4-quinolinylhydrazones derivatives
Bioorganic &amp; Medicinal Chemistry Letters 2009.0
New 1,3-oxazolo[4,5-c]quinoline derivatives: Synthesis and evaluation of antibacterial and antituberculosis properties
European Journal of Medicinal Chemistry 2010.0
Synthesis and in vitro biological evaluation of ring B abeo-sterols as novel inhibitors of Mycobacterium tuberculosis
Bioorganic &amp; Medicinal Chemistry Letters 2008.0