Stereoselective total synthesis of a novel regiomer of herbarumin I and its cytotoxic and antimicrobial activities

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

Stereoselective synthesis of a novel regiomer of the natural nonenolide, herbarumin I has been accomplished. The synthesis involves the coupling of the alcohol and acid fragments of the molecule using Yamaguchi protocol followed by intramolecular ring closing metathesis. The cytotoxic and antimicrobial properties of the synthetic regiomer have been studied.

Knowledge Graph

Similar Paper