Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities

Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: Identification of a lead for anti-inflammatory drug Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition Design, synthesis and anticancer activities of hybrids of indole and barbituric acids—Identification of highly promising leads Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids Chalcone derivatives bearing chromen or benzo[f]chromen moieties: Design, synthesis, and evaluations of anti-inflammatory, analgesic, selective COX-2 inhibitory activities Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents