Correlation of carbonic anhydrase inhibitory activities of benzenesulfonamides with the data obtained by use of nitrogen-14 nuclear quadrupole resonance

Journal of Medicinal Chemistry
1979.0

Abstract

Nitrogen-14 nuclear quadrupole resonance (NQR) spectra of several benzenesulfonamides in their solid state are reported and analyzed in the framework of the Townes and Dailey theory. Satisfactory correlations between the (sigma NH--sigma NS) electron densities at the sulfamyl nitrogen and the in vitro carbonic anhydrase inhibitory activities of the sulfonamides have been found. The correlations are in accord with the results of other studies that show the carbonic anhydrase inhibitory activities to be largely influenced by the electronic property of the sulfamyl group.

Knowledge Graph

Similar Paper

Correlation of carbonic anhydrase inhibitory activities of benzenesulfonamides with the data obtained by use of nitrogen-14 nuclear quadrupole resonance
Journal of Medicinal Chemistry 1979.0
The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships
Journal of Medicinal Chemistry 1989.0
Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase
Journal of Medicinal Chemistry 1993.0
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety
Bioorganic & Medicinal Chemistry 2013.0
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies
European Journal of Medicinal Chemistry 2021.0
Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors
Bioorganic & Medicinal Chemistry Letters 2016.0
Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: Design, synthesis, inhibitory activity and 3D-QSAR analysis
European Journal of Medicinal Chemistry 2013.0
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition
Bioorganic & Medicinal Chemistry 2013.0
N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II
Bioorganic & Medicinal Chemistry 2015.0
5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations
Bioorganic & Medicinal Chemistry 2017.0