5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline

Journal of Medicinal Chemistry
1979.0

Abstract

Treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the first quinone-modified analogue of either daunorubicin or adriamycin. This product retains antileukemic activity in mice, is less cardiotoxic by electrocardiographic measurements in rats, and is nonmutagenic in Salmonella typhimurium (Ames test).

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