Synthesis, antiproliferative and antibacterial activity of new amides of salinomycin

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

A series of 11 novel amides of salinomycin were synthesized for the first time. All the obtained compounds were found to show potent antiproliferative activity against human cancer cell lines including the drug-resistant cancer cells. Four new salinomycin derivatives revealed good antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE).

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