Antiviral activity of some .beta.-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses

Journal of Medicinal Chemistry
1977.0

Abstract

A series of aryloxy alkyl diketones II was synthesized and screened in vitro for antiviral activity. The effect of various substituents on the phenyl ring, as well as the length of the alkyl bridge, was examined to establish the requirements for optimum activity. One of the most active members of the series, 4-[6-(2-chloro-4-methoxy)phenoxy]hexyl-3,5-heptanedione (56), exhibited a high level of activity against both DNA and RNA viruses in both the tissue culture and organ culture screens and was particularly effective against herpesvirus type 1 and 2.

Knowledge Graph

Similar Paper

Antiviral activity of some .beta.-diketones. 2. Aryloxy alkyl diketones. In vitro activity against both RNA and DNA viruses
Journal of Medicinal Chemistry 1977.0
Antiviral activity of some .beta.-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses
Journal of Medicinal Chemistry 1977.0
Antiviral compounds. 1. Structure-activity relationship of some antiviral enediones derived from aldehydo sugars
Journal of Medicinal Chemistry 1983.0
Design, synthesis and preliminary antiviral screening of new N-phenylpyrazole and dihydroisoxazole derivatives
Medicinal Chemistry Research 2010.0
Synthesis and Biological Evaluation of Certain α,β-Unsaturated Ketones and Their Corresponding Fused Pyridines as Antiviral and Cytotoxic Agents
Journal of Medicinal Chemistry 2000.0
Antibacterial, antifungal and antioxidant activity of some new water-soluble β-diketones
Medicinal Chemistry Research 2013.0
Synthesis of new acridines and hydrazones derived from cyclic β-diketone for cytotoxic and antiviral evaluation
European Journal of Medicinal Chemistry 2009.0
Synthesis of some phosphonates with antiherpetic activity
Journal of Medicinal Chemistry 1984.0
Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl sidechain
Journal of Medicinal Chemistry 1992.0
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine
Journal of Medicinal Chemistry 1978.0