Literature

Abstract

Omega-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric, -hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times more potent than the octanoic analogue, and 0.43 times as potent as indomethacin.

DOI： 10.1021/jm00221a028

Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. .omega.-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)alkanoic acids

Journal of Medicinal Chemistry 1977.0

Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 1. 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acids

Journal of Medicinal Chemistry 1977.0

Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 2. Dihydro-10-oxofuro- and -thieno[3,2-c][1]benzoxepin-8-acetic acids

Journal of Medicinal Chemistry 1977.0

6,11-Dihydro-11-oxodibenz[b,e]oxepinacetic acids with potent antiinflammatory activity

Journal of Medicinal Chemistry 1976.0

Nonsteroidal antiinflammatory agents. 2. Derivatives/analogs of dibenz[b,e]oxepin-3-acetic acid

Journal of Medicinal Chemistry 1978.0

Dibenz[b,c]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4,10-dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-yl)butanol and -butyric acid and related derivatives