Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines

Journal of Medicinal Chemistry
1976.0

Abstract

A quantitative structure-activity relationship (QSAR) has been formulated for quinazolines causing 50% inhibition of liver dihydrofolate reductase. The QSAR for the quinazolines is compared with QSAR for triazine and pyrimidine inhibitors. The three QSAR suggest new possibilities for the design of inhibitors of mammalian dihydrofolate reductase.

Knowledge Graph

Similar Paper

Inhibition of dihydrofolate reductase. Structure-activity correlations of quinazolines
Journal of Medicinal Chemistry 1976.0
Quantitative structure-activity relation of antimalarial and dihydrofolate reductase inhibition by quinazolines and 5-substituted benzyl-2,4-diaminopyrimidines
Journal of Medicinal Chemistry 1977.0
Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. A quantitative structure-activity relationship analysis
Journal of Medicinal Chemistry 1984.0
On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships
Journal of Medicinal Chemistry 1989.0
Quantitative structure-activity relations of chymotrypsin. The predictive value of correlation equations
Journal of Medicinal Chemistry 1977.0
Quantitative Structure−Activity Relationships of 2,4-Diamino-5-(2-X-benzyl)pyrimidines versus Bacterial and Avian Dihydrofolate Reductase
Journal of Medicinal Chemistry 1998.0
Quantitative structure-activity relationship of 5-(X-benzyl)-2,4-diaminopyrimidines inhibiting bovine liver dihydrofolate reductase
Journal of Medicinal Chemistry 1979.0
Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted benzyl)-2,4-diaminopyrimidines
Journal of Medicinal Chemistry 1980.0
Inhibition of dihydrofolate reductase: structure-activity correlations of 2,4-diamino-5-benzylpyrimidines based upon molecular shape analysis
Journal of Medicinal Chemistry 1981.0
Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, x-ray crystallography, and computer graphics in structure-activity analysis
Journal of Medicinal Chemistry 1982.0