Antidepressant and Anticonvulsant Activity of 1-(5-Phenyl-4-oxo-2-oxazolin-2-yl)-4-substituted Piperazines

Journal of Medicinal Chemistry
1976.0

Abstract

1-(5-Phenyl-4-oxo-2-oxazolin-2-yl)-4-substituted cinnamoylpiperazines and 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)-4-carbamoylpiperazine and derivatives were synthesized and evaluated for antidepressant activity in the mouse Dopa potentiation test. 1-(5-Phenyl-4-oxo-2-oxazolin-2-yl)-4-carbamoylpiperazine and derivatives were further evaluated for anticonvulsant activity in the audiogenic seizure test in mice.

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