Cephalosporin derivatives with 2- and 4-pyridone groups at carbon-3

Journal of Medicinal Chemistry
1979.0

Abstract

Two compounds, analogues of cephalexin with 2- and 4-pyridone groups at C-3, were prepared. Biological evaluation found the compounds to exhibit activity against Gram-positive and Gram-negative organisms in vitro and in vivo. The compounds were only active in vivo on subcutaneous administration.

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