The synthesis and biological activity of a series of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles are described. These compounds are structurally related with Miconazole. In previous reports, the synthesis and antifungal effects of a large number of 2-substituted 2-phenylethyl-1H-imidazoles were described. One of these compounds, Miconazole (I), displays a marked broad-spectrum antimycotic activity and is now widely used as an antifungal drug. The aim of this paper is to describe the synthesis and antimycotic properties of a series of 1-[2-(aryloxyalkyl)-2-phenylethyl]-1H-imidazoles (II), which are structurally related to Miconazole.