Literature

Abstract

The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor suppressor PDCD4. Cytotoxicities in the 3 to 30 μM range were found. Both the cytotoxicity and PDCD4 stabilizing ability were tolerant of large stereochemical changes to the molecule. Co-dosing studies with cryptocaryols A and B and several known cancer drugs showed no measuable enhancement in cancer drug cytotoxicity.

DOI： 10.1021/ml4005039

Cryptocaryol Structure–Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4

ACS Medicinal Chemistry Letters 2014.0

Cryptocaryols A–H, α-Pyrone-Containing 1,3-Polyols from Cryptocarya sp. Implicated in Stabilizing the Tumor Suppressor Pdcd4

Journal of Natural Products 2011.0

Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity

Journal of Natural Products 2004.0

Total Synthesis and Antitubulin Activity of C10 Analogues of Cryptophycin-24

Journal of Medicinal Chemistry 2004.0

Synthesis and in vitro cytotoxicity of cryptophycins and related analogs

Bioorganic & Medicinal Chemistry Letters 1996.0

Semisynthetic Analogues of the Microtubule-Stabilizing Agent Discodermolide: Preparation and Biological Activity