Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease Inhibitors of hepatitis C virus NS3/4A: α-Ketoamide based macrocyclic inhibitors Discovery of a series of novel compounds with moderate anti-hepatitis C virus NS3 protease activity in vitro Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors Novel Peptidomimetic Hepatitis C Virus NS3/4A Protease Inhibitors Spanning the P2–P1′ Region Inhibitors of hepatitis C virus NS3·4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics Achiral Pyrazinone-Based Inhibitors of the Hepatitis C Virus NS3 Protease and Drug-Resistant Variants with Elongated Substituents Directed Toward the S2 Pocket Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease The Design, Synthesis, and Antiviral Activity of 4′-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4′-Azidoarabinocytidine Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety