Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities

Bioorganic & Medicinal Chemistry Letters
2015.0

Abstract

In the present study, a series of novel highly functionalized spiropyrrolidine-oxindoles have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide formed from isatin and various amino acids such as sarcosine, proline and thioproline with the dipolarophile (E)-3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile under optimized conditions. All the synthesized compounds were evaluated for their antimicrobial activity and shown significant activity.

Knowledge Graph

Similar Paper

Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens
Bioorganic & Medicinal Chemistry Letters 2008.0
Facile one-pot synthesis of novel dispirooxindole-pyrrolidine derivatives and their antimicrobial and anticancer activity against A549 human lung adenocarcinoma cancer cell line
Bioorganic & Medicinal Chemistry Letters 2013.0
Synthesis of novel spirooxindole derivatives by one pot multicomponent reaction and their antimicrobial activity
European Journal of Medicinal Chemistry 2012.0
Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives
European Journal of Medicinal Chemistry 2009.0
Synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines
European Journal of Medicinal Chemistry 2011.0
The discovery of oxazolones-grafted spirooxindoles via three-component diversity oriented synthesis and their preliminary biological evaluation
Bioorganic & Medicinal Chemistry Letters 2015.0
Azomethine ylide cycloaddition: a versatile tool for preparing novel pyrrolizidino-spiro-oxindolo hybrids of the doubly conjugated alkamide piperine
Molecular Diversity 2020.0
Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide
European Journal of Medicinal Chemistry 2010.0
Diversity-oriented sustainable synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives: New ligands for a metallo-β-lactamase from Klebsiella pneumonia
Bioorganic & Medicinal Chemistry Letters 2017.0