Class II but Not Second Class—Prospects for the Development of Class II PI3K Inhibitors

Class II but Not Second Class—Prospects for the Development of Class II PI3K Inhibitors Class II Phosphoinositide 3-Kinases as Novel Drug Targets Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective Small molecules targeting phosphoinositide 3-kinases Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring Comprehensive analysis of kinase inhibitor selectivity Evolution of PI3Kγ and δ Inhibitors for Inflammatory and Autoimmune Diseases Through the “Gatekeeper Door”: Exploiting the Active Kinase Conformation Synthesis and SAR study of potent and selective PI3Kδ inhibitors Rational design of inhibitors that bind to inactive kinase conformations