Antiprotozoal activity of 8-acyl and 8-alkyl incomptine A analogs

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

The activities of 11 C-8-O-acyl and alkyl analogs of the antiprotozoal sesquiterpene lactone, incomptine A (1) against Entamoeba histolytica and Giardia lamblia, were determined. Here, the effects of different lengths and amounts of branching of the acyl and alkyl groups on the antiprotozoal activity of the synthesized incomptine A-analogs are reported.

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