Synthesis of Tripeptides Containing d-Trp Substituted at the Indole Ring, Assessment of Opioid Receptor Binding and in Vivo Central Antinociception

Synthesis of Tripeptides Containing <scp>d</scp>-Trp Substituted at the Indole Ring, Assessment of Opioid Receptor Binding and in Vivo Central Antinociception Opioid Activity Profiles of Oversimplified Peptides Lacking in the Protonable N-Terminus Versatile Picklocks To Access All Opioid Receptors: Tuning the Selectivity and Functional Profile of the Cyclotetrapeptide c[Phe-<scp>d</scp>-Pro-Phe-Trp] (CJ-15,208) Potent μ-Opioid Receptor Agonists from Cyclic Peptides Tyr-c[<scp>d</scp>-Lys-Xxx-Tyr-Gly]: Synthesis, Biological, and Structural Evaluation Discovery of κ Opioid Receptor (KOR)-Selective <scp>d</scp>-Tetrapeptides with Improved In Vivo Antinociceptive Effect after Peripheral Administration Synthesis of oxytocin antagonists containing conformationally constrained amino acids in position 2 Analgesic dipeptide derivatives. 4. Linear and cyclic analogs of the analgesic compounds arginyl-2-[(o-nitrophenyl)sulfenyl]tryptophan and lysyl-2-[(o-nitrophenyl)sulfenyl]tryptophan Stereospecific synthesis of (2 S )-2-methyl-3-(2′,6′-dimethyl-4′-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide Synthesis and binding activity of endomorphin-1 analogues containing β-amino acids Dermorphin tetrapeptide analogues with 2′,6′-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high μ opioid receptor binding and biological activities1