Phenolic Diterpenoid Derivatives as Anti-Influenza A Virus Agents

ACS Medicinal Chemistry Letters
2015.0

Abstract

A series of diterpenoid derivatives based on podocarpic acid were synthesized and evaluated as anti-influenza A virus agents. Several of the novel podocarpic acid derivatives exhibited nanomolar activities against an H1N1 influenza A virus (A/Puerto Rico/8/34) that was resistant to two anti-influenza drugs, oseltamivir and amantadine. This class of compounds inhibits the influenza virus by targeting the viral hemagglutinin-mediated membrane fusion. These results indicated that podocarpic acid derivatives may serve as potential drug candidates to fight drug-resistant influenza A virus infections.

Knowledge Graph

Similar Paper

Phenolic Diterpenoid Derivatives as Anti-Influenza A Virus Agents
ACS Medicinal Chemistry Letters 2015.0
Synthesis, structure activity relationship and in vitro anti-influenza virus activity of novel polyphenol-pentacyclic triterpene conjugates
European Journal of Medicinal Chemistry 2019.0
Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein
Journal of Medicinal Chemistry 2012.0
Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors
MedChemComm 2016.0
Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus
MedChemComm 2017.0
Novel amides modified rupestonic acid derivatives as anti-influenza virus reagents
Bioorganic & Medicinal Chemistry Letters 2019.0
Design, synthesis and in vitro anti-influenza A virus evaluation of novel quinazoline derivatives containing S-acetamide and NH-acetamide moieties at C-4
European Journal of Medicinal Chemistry 2020.0
Influenza antiviral activity of F- and OH-containing isopulegol-derived octahydro-2H-chromenes
Bioorganic & Medicinal Chemistry Letters 2021.0
Identification and Synthesis of Quinolizidines with Anti-Influenza A Virus Activity
ACS Medicinal Chemistry Letters 2014.0
Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors
European Journal of Medicinal Chemistry 2014.0