Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones

Bioorganic & Medicinal Chemistry Letters
2015.0

Abstract

A series of novel 8-azapurine carbocyclic nucleoside hydrazones were synthesized through a useful procedure starting from amino alcohol and pyrimido dichloride. All the products were characterized by (1)H NMR, (13)C NMR and HRMS spectral analysis and the stereochemical structure of key intermediate was also confirmed by a single crystal X-ray diffraction crystallographic analysis. Moreover, the anticancer activities were evaluated in vitro against human liver cancer Huh-7 cell line and human breast cancer A549 cell line.

Knowledge Graph

Similar Paper

Synthesis and anticancer activities of novel 8-azapurine carbocyclic nucleoside hydrazones
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis and cytotoxic activity of novel 3-(1H-indol-3-yl)-1H-pyrazole-5-carbohydrazide derivatives
European Journal of Medicinal Chemistry 2011.0
Acylhydrazone derivatives as potential anticancer agents: Synthesis, bio-evaluation and mechanism of action
Bioorganic & Medicinal Chemistry Letters 2015.0
Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity
European Journal of Medicinal Chemistry 2010.0
Heterocycles 23: Synthesis, characterization and anticancer activity of new hydrazinoselenazole derivatives
Medicinal Chemistry Research 2013.0
Synthesis and biological evaluation of novel homochiral carbocyclic nucleosides from 1-amino-2-indanols
Bioorganic & Medicinal Chemistry 2012.0
Synthesis of novel hydrazone and azole functionalized pyrazolo[3,4-b]pyridine derivatives as promising anticancer agents
Bioorganic & Medicinal Chemistry Letters 2016.0
Synthesis, anticancer activity and photophysical properties of novel substituted 2-oxo-2H-chromenylpyrazolecarboxylates
European Journal of Medicinal Chemistry 2013.0
Synthesis and cytotoxic activities of some pyrazoline derivatives bearing phenyl pyridazine core as new apoptosis inducers
European Journal of Medicinal Chemistry 2016.0