Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents

MedChemComm
2014.0

Abstract

The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a human infective strain of the trypanosome parasite, that serve as lead compounds for further optimisation.

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