Analogues of boswellic acids as inhibitors of pro-inflammatory cytokines TNF-α and IL-6

Bioorganic & Medicinal Chemistry Letters
2016.0

Abstract

A library of boswellic acid analogues were synthesized and tested for their anti-inflammatory potential on key inflammatory mediators, TNF-α and IL-6. The study led to the identification of lead compounds showing significant inhibition of the cytokines, TNF-α and IL-6 both in vitro and in vivo.

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