Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors

Exploring the importance of zinc binding and steric/hydrophobic factors in novel HCV replication inhibitors Synthesis and evaluation of novel potent HCV NS5A inhibitors Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase 4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase Hydroxamic Acids Block Replication of Hepatitis C Virus Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors Synthesis and structure-activity relationship study of new biaryl amide derivatives and their inhibitory effects against hepatitis C virus The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase