LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

Journal of Natural Products
2016.0

Abstract

Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.

Knowledge Graph

Similar Paper

LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18
Journal of Natural Products 2016.0
Antimicrobial Furancarboxylic Acids from a <i>Penicillium</i> sp.
Journal of Natural Products 2020.0
Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006
International Journal of Molecular Sciences 2024.0
Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp.
Bioorganic &amp; Medicinal Chemistry Letters 2010.0
Antifungal metabolites from the rhizospheric Penicillium sp. YIM PH 30003 associated with Panax notoginseng
Phytochemistry Letters 2015.0
Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum
Phytochemistry 2008.0
Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated <i>Sphaerimonospora mesophila</i>
Journal of Natural Products 2018.0
New chromone analog and pyrrole alkaloid produced by Penicillium sclerotiorum and their antibacterial activity
Journal of Asian Natural Products Research 2023.0
Penicillenols from Penicillium sp. GQ-7, an Endophytic Fungus Associated with Aegiceras corniculatum
Chemical and Pharmaceutical Bulletin 2008.0
Furo[3,2-h]isochroman, furo[3,2-h]isoquinoline, isochroman, phenol, pyranone, and pyrone derivatives from the sea fan-derived fungus Penicillium sp. PSU-F40
Tetrahedron 2010.0